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Transformation reaction of prenylated chalcone of pinostrobin derivative and their antibacterial activity
Marliyana S.D.a, Mujahidin D.b, Syah Y.M.b
a Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sebelas Maret University, Surakarta, Indonesia
b Department of Chemistry, Faculty of Mathematics and Natural Sciences, Laboratory of Natural Products, Institut Teknologi Bandung, Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2019 Published under licence by IOP Publishing Ltd.The transformation reaction of chalcone prenylation of pinostrobin derivatives has been done. The pinostrobin was isolated from Kaempferiapandurata rhizome which is the main component. The transformation reaction was approved by reacting monooxyprenylated chalcone (1) through zinc chloride (ZnCk) and toluene. The purification of the product was performed with chromatographic methods (radial chromatography and thin layer chromatography). Four compounds have been achieved from the transformation reaction, i.e. monocyclicprenylated chalcone (2), monocyclicprenylated pinostrobin (3), monoprenylated chalcone (4), and monoprenylated pinostrobin (5). The elucidation structures of the compounds were confirmed on the spectra of 1H NMR, 13C NMR, and mass spectrometry data. The antibacterial activity was valued using the minimum inhibitory concentration (MIC) against five bacteria, namely, Staphylococcus aureus ATCC 29737, Proteus mirabilis ATCC 21100, Bacillus subtilis ATCC 6633, Klebsiella pneumoniae ATCC 13733, and Escherichia coli O157:H7. The compound 4 showed a potential compound as antibacterial activity against Bacillus subtilis ATCC 6633 (MIC 7,8 μg/mL) and Proteus mirabilis ATCC 21100 (15,6 μg/mL) bacteria.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Anti-bacterial activity,Chromatographic methods,Escherichia coli O157:H7,Klebsiella pneumoniae,Mass spectrometry data,Minimum inhibitory concentration,Staphylococcus aureus,Transformation Reactions[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]This research was financially supported by the Scholarship of Doctoral Degree (BPDN) from the Higher Education Directorate, Ministry of Education, Indonesia.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.1088/1757-899X/509/1/012133[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]