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Polymorphic properties and dissolution profile of efavirenz due to solvents recrystallization
Wardhana Y.W.a,b, Soewandhi S.N.a, Wikarsa S.a, Suendo V.a
a Department of Pharmaceutics, School of Pharmacy, Institute Technology of Bandung, Bandugn, Indonesia
b Department of Pharmaceutics and Pharmaceuticals Technology, Faculty of Pharmacy, University of Padjadjaran, Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2019 Pakistan Journal of Pharmaceutical Sciences. All rights reserved.Polymorphism occurs in pharmaceutical compounds affect to the physicochemical quality and goal of therapy. Thus, quality evaluation of different crystal forms should be assessed especially the solubility and dissolution behaviors among polymorphic forms, which correlate to bioavailability and therapy efficacy. To achieved the different of a polymorph various solvent were used such as acetonitrile, methanol, ethyl acetate, acetone, water, n-hexane, and n-heptane. All of the crystal modification resulted were characterized by a polarization light microscopy (PLM), Fourier-Transform Infrared (FTIR) differential scanning calorimetry (DSC) and powdered X-ray diffraction (PXRD). Besides that, nature of solubility in water (24 and 48 hours test times) and particulate dissolution profile (an hour test) were carried out. There were various polymorphs success resulted and have significant differences in morphology, definite spectral fingerprints, crystal structure and thermal behavior. From the solubility of the samples found the top three highest soluble forms i.e. Form 6, 2 and 3, respectively. But there are showed became in order reverse performance after 60 minutes dissolution (Form 3, 2 and 6, respectively). The polymorphic forms of EFV were successful to obtained by the solvents treatment. Therefore, the physicochemical properties of polymorphic forms from active pharmaceutical ingredients (APIs) should be carefully considered in dosage forms pre-formulation approaches.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Acetone,Acetonitriles,Benzoxazines,Calorimetry, Differential Scanning,Crystallization,Hexanes,Methanol,Microscopy, Polarization,Solubility,Solvents,Spectroscopy, Fourier Transform Infrared,Water,X-Ray Diffraction[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Dissolution profile,Efavirenz,Polymorph properties,Polymorphism,Solubility[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]