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Morphological analysis of Goniopora species coral powder and composite scaffold using micro-computed tomography
Julia V.a, Latief F.D.E.b, Mauludin R.b, Kartasasmita R.E.b, Latief B.S.a
a Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia
b Micro-CT Laboratory, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung, 40132, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2019 Journal of International Dental and Medical Research.Coral is considered useful for scaffold formation because of its osteoconductivity, biocompatibility, and good resorption properties. To further facilitate the optimal clinical application in oral surgery, Goniopora species coral powder has been formulated into an appropriate semi solid composite scaffold to fulfill pharmaceutical safety, efficacy, and quality requirements. The aim of this study was to analyze the morphological structure of goniopora coral powder and its composite scaffolds. Composite bone graft was formulated by mixing Goniopora sp. coral powder with a sterile semisolid base made of excipient mixture (polyvinylpyrrolidone and poloxamer 188, 1:1). The prepared coral raw material, coral powder, and its composite scaffold were observed under a scanning electron microscope (SEM), and the morphological structures of Goniopora sp. coral powder and its composite scaffold were analyzed by micro-computed tomography (μ-CT). SEM observations of Goniopora sp. raw material, coral powder particles, and its composite scaffold revealed a good mineral phase distribution network. The histogram of the gray scale index of μ-CT scan revealed the sample’s composition in terms of its components’ pseudo-density. The mixture of the coral powder and the sterile semisolid base increased the resultant powder particle density and formed a composite coral scaffold, suggesting the suitability of the excipient mixture as an adhesive agent.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Electron microscope tomography,Micro-computed tomography,Tissue scaffold[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]The author gratefully acknowledge Basril Abbas, from National Nuclear Energy Agency of Indonesia (BATAN) to assist the preparation of Coral Goniopora powder particle.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]