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Synthesis of [Mn(Salen)Cl] complex compound and superoxide dismutase activity determination through non-enzymatic method
Deawati Y.a, Onggo D.b, Mulyani I.b, Hastiawan I.a, Utami R.A.b, Kurnia D.a
a Physical and Inorganic Chemistry Laboratory, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, Sumedang, 45363, Indonesia
b Inorganic and Physical Chemistry Research Group, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung, 40132, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2019 Trans Tech Publications Ltd, Switzerland.Superoxide dismutase (SOD) is an Mn-containing enzyme that catalyzes the conversion of superoxide (O2•) into O2 and H2O2. To develop a small, non-protein Mn-containing SOD mimic, an [Mn(salen)Cl] complex was synthesized from MnCl2.4H2O and H2salen. The product yielded 75-90% reddish dark brown crystals indicative of the presence of manganese(III) metal ions. An elemental analysis showed that the compound contained: C = 48.36%; H = 4.34%; and N = 7.13%. Infrared spectra of this compound showed peaks at: u(OH)=3426 (medium), u(C=N)=1634 (very high), u(CO)=1292 (high). An ESI-MS analysis (m/z) showed the presence of ionic species from the complex including (salen)(H+) = 269.0 and [Mn(salen)]+ = 320.9. Conductivity measurements revealed that the compound is neutral with a molar conductivity of 0.17 mS. Its magnetic moment of 5.2 BM was obtained from a magnetic susceptibility balance measurement, showing that the compound is paramagnetic. The SOD activity of this compound was given by IC50 = 2.5 ± 0.3 μM in a non-enzymatic riboflavin photoreduction in vitro test.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Complex,Dismutase,Mimic,Superoxides,[Mn(salenCl][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Complex,Dismutase,Mimic,SOD,Superoxide,[Mn(salenCl][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][{‘$’: ‘This study was supported by the research grants of the doctoral dissertation of “Hibah Disertasi Doktor 2017” with a contract number of 718/UN6.3.1/PL/2017 from the Directorate General of Higher Education (DIKTI). We would like to thank Prof. Dr. Evamarie Hey-Hawkins from Universit?t Leipzig, Germany, for the CHN, FTIR, and ESI-MS analysis, and also thank to Dr. Debbie Soefie Retnoningrum from School of Pharmacy, Institut Teknologi Bandung, Indonesia, for the measurement using microplate reader.’}, {‘$’: ‘This study was supported by the research grants of the doctoral dissertation of “Hibah Disertasi Doktor 2017” with a contract number of 718/UN6.3.1/PL/2017 from the Directorate General of Higher Education (DIKTI). We would like to thank Prof. Dr. Evamarie Hey-Hawkins from Universität Leipzig, Germany, for the CHN, FTIR, and ESI-MS analysis, and also thank to Dr. Debbie Soefie Retnoningrum from School of Pharmacy, Institut Teknologi Bandung, Indonesia, for the measurement using microplate reader.’}][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.4028/www.scientific.net/KEM.811.22[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]