2-s2.0-85074015153

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[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2019 Informa UK Limited, trading as Taylor & Francis Group.Fractionation and purification of the ethyl acetate extract of Diaporthe lithocarpus, an endophytic fungus from the leaves of Artocarpus heterophyllus, yielded one new compound, diaporthindoic acid (1), along with seven known compounds (2–8). The new compound was characterized and established by the basis of extensive spectroscopic methods including NMR (1D and 2D) and HRMS. Compound 6 showed the best citotoxicity against murine leukemia P-388 cells with an IC50 value of 0.41 μg/mL. All compounds (1–8) were also tested for their antimicrobial activities. To the best of our knowledge, this is the first chemical evaluation of fungal Diaporthe derived from Artocarpus.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Antimicrobial,Artocarpus,cytotoxicity,Diaporthe,secondary metabolites[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][{‘$’: ‘The authors extend their appreciation to the Ministry of Research, Technology and Higher Education of Indonesia for the PKPI/Sandwich like-PMDSU Scholarship (grant number: 859/D3/PG/2018). The authors are grateful to the staff and students of Technical Biochemistry, Technical University Dortmund, Germany for providing us with the facilities during the course of this research. We are also thankful to The World Academy of Science (TWAS) for instrument biosafety at Institut Teknologi Bandung.’}, {‘$’: ‘The authors extend their appreciation to the Ministry of Research, Technology and Higher Education of Indonesia for the PKPI/Sandwich like-PMDSU Scholarship (grant number: 859/D3/PG/2018). The authors are grateful to the staff and students of Technical Biochemistry, Technical University Dortmund, Germany for providing us with the facilities during the course of this research. We are also thankful to The World Academy of Science (TWAS) for instrument biosafety at Institut Teknologi Bandung.’}, {‘$’: ‘Antimicrobial ; Artocarpus ; Diaporthe ; cytotoxicity ; secondary metabolites Ministry of Research, Technology and Higher Education of Indonesia for the PKPI/Sandwich like-PMDSU Scholarship 859/D3/PG/2018 1.’}][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.1080/14786419.2019.1672685[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]