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Effects of thermal energy, mechanical energy, and solvent on ciprofloxacin hydrochloride monohydrate physicochemical properties
Widyastuti I.a, Ainurofiq A.b, Soewandhi S.N.a
a School of Pharmacy, Institut Teknologi Bandung, Bandung, 40132, Indonesia
b Department of Pharmacy, Universitas Sebelas Maret, Surakarta, 57126, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© RASĀYAN.Ciprofloxacin HCl is available in the form of anhydrate and monohydrate. Water content can affect the hydrolysis, hygroscopicity, bond, and crystal properties of an active substance. This study was aimed to observe the physicochemical phenomena that occur in ciprofloxacin HCl monohydrate because of thermal energy, mechanical energy, and solvent. Ciprofloxacin HCl monohydrate from two different producers were given treatments by thermal energy, mechanical energy, and solvent. Afterward, the ingredients were characterized using XRD, DSC, and SEM. Other than that, crystal habit, modulus of elasticity, and dissolution were assessed. The results of characterization before and after treatment were compared to observe any changes. Ciprofloxacin HCl monohydrate from two different producers showed similarities in physicochemical properties. Manufacture treatment, which includes thermal energy, mechanical energy, and solvent, affected the physicochemical characteristics of ciprofloxacin HCl monohydrate. The effect of thermal energy and solvent can change ciprofloxacin from hydrate to anhydrate, thus changed its dissolution level. Meanwhile, mechanical effect by grinding and compression can decrease crystallinity and change the particle size of ciprofloxacin HCl monohydrate, thus change its dissolution level. The results of this study showed that the process of manufacturing can change the physicochemical characteristics of ciprofloxacin HCl monohydrate.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Ciprofloxacin HCl monohydrate,Mechanical energy,Physicochemical property,Solvent,Thermal energy[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.31788/RJC.2019.1245426[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]