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New Preparation Method Using Microwave, Kinetics, In Vitro Dissolution-Diffusion, and Anti-Inflammatory Study of Diclofenac- Proline Co–Crystal
Nugrahani I.a, Utami D.b, Ayuningtyas L.a, Garmana A.N.a, Oktaviary R.a
a Department of Pharmacochemistry, School of Pharmacy, Bandung Institute of Technology Bandung, Indonesia, Indonesia
b Faculty of Pharmacy, Ahmad Dahlan University Yogyakarta, Indonesia, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, WeinheimIn this study, we developed a novel and simple method to prepare an established diclofenac-proline co-crystal (DPC) using microwave. In addition, we also evaluate the pharmaceutical properties of the co-crystal, including dissolution, diffusion, and anti-inflammatory profile. The kinetics of co-crystal formation was investigated using Fourier-transform infrared spectroscopy. The co-crystal yield was confirmed physically by differential scanning calorimetry and powder x-ray diffraction, while the chemical stability of the drug during and after microwaving was confirmed using thin layer chromatography, ultraviolet spectrophotometry and high-performance liquid chromatography. Experiment results demonstrated that microwave can generate the stable and uniform quality of diclofenac-proline co-crystal efficiently. Furthermore, the process was investigated to follow a second order kinetic, which is different than the neat-grinding process previously reported. Moreover, our findings revealed that co-crystals with L-proline can significantly improve the dissolution, diffusion, and anti-inflammation activity of diclofenac acid.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]crystal engineering,diclofenac,drug delivery,L-proline,microwave chemistry[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]This research was supported by Research and Community Service of Bandung Institute of Technology, Indonesia, by Community Service and Innovation Program Funding Program, 2018. Some parts of experiments were supported by Uekusa’s Laboratory, Tokyo Institute of Technology.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.1002/slct.201903342[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]