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Antidiabetic activity of Tenebrio molitor linn powder by oral glucose tolerance test to swiss webster male mice
Samsul E.a, Soemardji A.A.b, Kusmardiyani S.b, Kuncoro H.a,c
a Laboratorium Riset dan Pengembangan Kefarmasian Farmaka Tropis, Fakultas Farmasi, Mulawarman University, Samarinda, 75119, Indonesia
b Pharmacology–Clinical Pharmacy Research Group, School of Pharmacy, Institut Teknologi Bandung, Indonesia
c Scientific Consortium of Drug Discovery and Development, Universitas Padjadjaran, Sumedang, West Java, 45363, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2020 World Research Association. All rights reserved.Tenebrio molitor Linn. is used by Indonesian people as a drug to reduce blood sugar levels. This study aims to examine the activity of Tenebrio molitor powder as antidiabetic. This research method used male mice with bodyweight 25-25 g, ages 2-3 months and divided into five groups with five male mice for each group. One group as negative control used CMC Na (1%) and one group as comparison control used Glibenclamide (5 mg/kg). This experiment used Oral Glucose Tolerance test procedure with modification. Administration of Tenebrio molitor powder dose 90 mg/kg BW and 45 mg/kg BW reduced blood glucose levels for 120 minutes with percentage 24,2% and 27,7% on glucose load, 22,4% and 21,9% on sucrose load, 17% and 21,7% on amylum load. The percentage decrease in blood glucose levels was lower than the comparison group of glibenclamide (5 mg/kg BW) with a percentage of 36,8% in glucose load, 23,2% in sucrose load and 22,6% in amylum load. Based on the evaluation results of the Tenebrio molitor powder with glucose tolerance method at doses 45 and 90 mg/kg BW had antidiabetic activity, but its strength was lower compared to glibenclamide.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Antidiabetic Activity,Oral glucose tolerance test,Tenebrio molitor Linn powder[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]