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Formation of electrosprayed composite nanoparticles from polyvinylpyrrolidone/mangosteen pericarp extract
Rezeki Y.A.a,b, Hapidin D.A.a,b, Rachmawati H.c,d, Munir M.M.a,b, Khairurrijal K.a,b
a Department of Physics, Faculty of Mathematics and Natural Sciences, Indonesia
b Bioscience and Biotechnology Research Center, Institute for Research and Community Services, Indonesia
c Pharmaceutics Research Division, School of Pharmacy, Indonesia
d Nanoscience and Nanotechnology Research Center, Institute for Research and Community Services, Institut Teknologi Bandung, Bandung, 40132, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2020 The Society of Powder Technology JapanMangosteen pericarp contains a lot of α-mangostin compounds which has very high antioxidant activity. Unfortunately, it has a low solubility in aqueous solution in which for drug delivery application. This paper reports the synthesis of polyvinylpyrrolidone (PVP) nanoparticles loaded with mangosteen pericarp extract (MPE) using the ES method. PVP was trusted as a hydrophilic matrix to carry MPE. The composition of the precursor solution and solution flow rate during the ES process were varied to control the formation of PVP/MPE composite nanoparticles. PVP/MPE composite particles obtained have some wrinkles on their surface and have a geometric average diameter range of 640 to 1534 nm with a geometric standard deviation of 1.35 to 1.65. Increasing the electrical conductivity of the precursor solution resulted in a decrease of nanoparticles’ average diameter. Also, the greater the flow rate, the larger the particles formed. The results agreed well with the droplet scaling relations for EHDA by Chen and Pui. Peak shifts in Fourier-transform infrared spectra of PVP/MPE composite nanoparticles indicated hydrogen bond formation between PVP and MPE. It also showed that MPE was successfully encapsulated in PVP matrix. Crystalline peaks of MPE disappear in the X-ray diffraction patterns of PVP/MPE composite nanoparticles, indicating amorphization of MPE after being electrosprayed by PVP. The differential scanning calorimetry study confirmed a hygroscopicity of PVP. The thermogram shows a broad endothermic peak from around 50 to 100 °C as a result of dehydration. In this study, the use of flow rate during the electrospraying process only affected the geometric average diameter, did not change the functional groups, thermal properties, and crystallinity of PVP/MPE particles because they came from the same precursor solution. The results here demonstrate that the ES method can be used for polymeric-nanoparticle-composite production and as an innovation in the field of drug delivery application.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Composite nanoparticles,Drug delivery applications,Electrospray method,Fourier transform infrared spectra,Geometric standard deviations,Hydrogen-bond formation,Mangosteen pericarp extract,Poly vinyl pyrrolidone[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Composite nanoparticles,Electrospray method,Mangosteen pericarp extract,Polyvinylpyrrolidone[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]This research was financially supported by the Directorate of Research and Community Engagement, Ministry of Research, Technology, and Higher Education, the Republic of Indonesia, under the University’s Excellence Research (PUPT) Grant in the fiscal year of 2017-2019 and the Dissertation Research of 2019. We also gratefully acknowledge the Ministry of Research, Technology, and Higher Education, the Republic of Indonesia for the provision of master and doctoral scholarship (PMDSU) of Y. A. R. and D. A. H.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.1016/j.apt.2020.02.016[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]