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Improving telmisartan mechanical properties through the formation of telmisartan and oxalic acid co-crystal by slow evaporation and ultrasound assisted co-crystallization from solution methods
Ratih H.a,b, Pamudji J.S.a, Alatas F.b, Soewandhi S.N.a
a Pharmaceutics Group, School of Pharmacy, Bandung Institute of Technology, Kota Bandung, 40132, Indonesia
b Pharmaceutics Group, Faculty of Pharmacy, University of Jenderal Achmad Yani, Kota Cimahi, 40531, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2020, Prince of Songkla University. All rights reserved.Telmisartan (TMS) is used for the prevention and treatment of hypertension. However, it has poor mechanical properties. The purpose of this research was to improve the mechanical properties of TMS through the formation of co-crystal TMS with oxalic acid (OXA) and to compare the mechanical properties of TMS-OXA 1:1 co-crystal obtained from the different co-crystallization techniques. Co-crystals were prepared by the slow evaporation (SE) and ultrasound assisted co-crystallization from solution (USSC) methods. The tabletability profiles were plotted between compaction forces in the range of 4.98‒29.89 kN vs. tensile strength. The tablet tensile strength of TMS in compaction force >14.98 kN had severe capping or lamination. In contrast, the tablet tensile strengths of the TMS-OXA SE and USSC co-crystals were higher and could be easily formed into tablets in all of the compaction forces. It can be concluded that the TMS-OXA co-crystals prepared by the SE and USSC methods have improved mechanical properties of the telmisartan tablet.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Co-crystal,Oxalic acid,Slow evaporation,Telmisartan,Ultrasound assisted co-crystallization from solution[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]We would like to thank the Directorate General of Higher Education, Indonesia Ministry of Education and Culture for the doctoral educational program scholarship.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.14456/sjst-psu.2020.25[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]