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Antimicrobial and anti-HCV activity of triterpenoid and alkaloid compounds from Melochia umbellata (Houtt.) Stapf var Visenia (Paliasa)
Nusan S.a, Soekamto N.H.a, Firdaus F.a, Syah Y.M.b
a Hasanuddin University, Kota Makassar, Indonesia
b Bandung Institute of Technology, Kota Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2020 Sapriansyah Nusan et al.feruloyloctopamine from Melochia umbellata (Houtt.) Stapf var Visenia. Both of these compounds were tested as an antimicrobial and anti-HCV activity. Isolation has been done by maceration, fractionation, and purification. The molecular structure was determined by IR spectroscopy and nuclear magnetic resonance (NMR) 1,2D (1H-NMR, 13C-NMR, HSQC, and HMBC). Antimicrobial assay of 3-acetyl-12-en-28-oic acid showed a zone of inhibition in the criteria of moderate to active against Escherichia coli (8.4 mm), Salmonella thypi (11.2 mm), Staphylococcus aureus (10.8 mm), and Candida albicans (8.5 mm), as well as compounds (R)-N-trans-feruloyloctopamine that is against E. coli (7.0 mm), S. thypi (10.55 mm), S. aureus (9.1 mm), and C. albicans (7.9 mm). Anti-HCV tests on the two compounds showed IC50 values of 52.07 and 45.02 μg/ml, respectively. The results of these tests indicate that the two compounds are potential as an antibiotic candidate.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Alkaloid,Anti-HCV,Antimicrobial,Melochia umbellata,Triterpenoid[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]The authors would like to thank the honorable head of the Organic Chemistry Laboratory at the Chemistry Department of Hasanuddin University who has provided the facilities to conduct this research, head of the Organic Chemistry Laboratory at the Bandung Institute of Technology, and staffs who have helped obtain NMR spectroscopic data. The authors also like to thank the Head of the Microbiology Laboratory at the Medical School of Hasanuddin University for antimicrobial assay and Head of the Institute of Tropical Disease, Airlangga University which has helped anti-HCV assay.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.7324/JAPS.2020.104017[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]