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Five 7-amino-4-methyl-2(1H)-quinolone derivatives and their antibacterial and antifungal evaluation
Dianhar H.a, Syah Y.M.b, Mujahidin D.b
a Chemistry Study Program, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta, Jakarta Timur, 13220, Indonesia
b Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Kota Bandung, 40132, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2020 World Research Association. All rights reserved.Quinolin-2(1H)-one derivatives have been found in nature particularly in the species of Rutaceae. Some of them are known as bioactive compounds. In this research, five 2(1H)-quinolone derivatives, namely 7-amino-4-methyl-2(1H)-quinolone (1), N-4-methyl-7((3-methylbut-2-en-1-yl)amino)quinolin -2(1H)-one (2), 7-(bis-(3-methylbut-2-en-1-yl) amino)-4methylquinolin-2(1H)-one (3), N-(4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)acetamide (4), N-(4-methyl-2oxo-1,2-dihydroquinolin-7-yl) benzamide (5) have been described. Structures of the synthetic compounds were determined by NMR, UV and mass spectral data. Antibacterial and antifungal evaluation of the synthetic compounds 1-5 showed that these compounds were inactive as antibacterial, but active against C. albicans. Thus, 7-amino-4-methyl-2(1H)-quinolone derivatives 1-5 can be developed further as antifungal agents.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Antibacterial,Antifungal,Bioactive,Quinolin-2(1H)-one[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]We are very thankful to the financial support to one of us (HD) in the form of Ph.D. scholarship from the office of Kemenristekdikti (BPPDN) 2013.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]