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Antibacterial activity of extract and two secondary metabolite compounds from the leaves of Hydrangea macrophylla
Agustini D.M.a, Hermawati E.b, Widianingsih S.a, Yun Y.F.a, Rengganis F.a
a Chemistry Department, Faculty of Science and Informatics, Universitas Jenderal Achmad Yani, Cimahi, 40528, Indonesia
b Chemistry Department, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung, 40132, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2020 World Research Association. All rights reserved.This research aims to obtain antibacterial compound from leaves of Hydrangea macrophylla. The isolation stage started with the extraction by using n-hexane and methanol. Then the methanol extract was separated by Vacuum Liquid Chromatography (VLC) method and was purified by Radial Chromatography which was guided by Thin Layer Chromatography (TLC) method. Two secondary metabolites were isolated i.e. (-)- hydrangenol and thunberginol A. Their chemical structures have been determined on the basis of chemical and physicochemical evidence. The antibacterial assay was performed by microdilution method against bacteria pathogenic: Salmonella thypi, Shigella dysenteriae, Escherichia coli, Staphylococcus aureus, Pseudomonas aureginosa and Klebsiella pneumoniae. On antibacterial test both compound were found as mostly weak antibacterials.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text](-)-hydrangenol,Antibacterial activity,Hydrangea macrophylla,Thunberginol A[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]This research was financially supported by Lembaga Penelitian dan Pengabdian Masyarakat (LPPM) Jenderal Achmad Yani University (scheme Hibah Kompetitif). We thank microbiology laboratory, Politeknik Kesehatan Bandung for their help with testing antibacterial activity.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]