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Sonochemical synthesis of magnetic Fe3O4/graphene nanocomposites for label-free electrochemical biosensors
Suhanto R.N.a, Harimurti S.a, Septiani N.L.W.a, Utari L.a, Anshori I.a, Wasisto H.S.b, Suzuki H.c, Suyatmana, Yuliarto B.a
a Advanced Functional Materials (AFM) Laboratory, Department of Engineering Physics, Institut Teknologi Bandung, Bandung, 40132, Indonesia
b Institute of Semiconductor Technology (IHT) and Laboratory for Emerging Nanometrology (LENA), Technische Universität Braunschweig, Braunschweig, 38106, Germany
c Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, 305-8573, Japan
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2020, Springer Science+Business Media, LLC, part of Springer Nature.This work reports on sonochemical synthesis of carbon paste electrodes modified with magnetic Fe3O4/graphene nanocomposites as a label-free electrochemical biosensor for prostate-specific antigen detection. To optimize their properties as a biosensor, the compositions of both Fe3O4 and graphene were varied. The as-synthesized nanocomposites possess good crystallinity and purity with Fe3O4 nanoparticles attached onto the graphene surface. From voltammetry measurements, the modified electrode shows an increase of reduction peaks as compared to the bare electrode which promisingly led to a more sensitive biosensing detection. The modified electrode was then used for biomarker detection through the immobilization of the anti-prostate-specific antigen (anti-PSA) antibodies onto it. The results showed that the electrochemical signal increased linearly against PSA concentration, from 1 to 150 ng/mL, with a detection limit of 0.38 ng/mL. Having all these characteristics, the Fe3O4/graphene nanocomposites offer a promising path towards the development of highly sensitive prostate biosensors, especially for cancer detection.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Carbon paste electrode,Electrochemical biosensor,Electrochemical signals,Fe3O4 nanoparticles,Modified electrodes,Prostate specific antigen,Sonochemical synthesis,Voltammetry measurements[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][{‘$’: ‘This work is partially supported by the Ministry of Education and Culture and Ministry of Research and Technology under the grant scheme of the World Class University (WCU) Program managed by Institut Teknologi Bandung. Authors also acknowledge finance support from Institut Teknologi Bandung, Indonesia, and research grant from the Ministry of Education and Culture and Ministry of Research and Technology of Republic of Indonesia. H.S. Wasisto acknowledges the financial support from Lower Saxony Ministry for Science and Culture (N-MWK) for LENA-OptoSense group and RISTEKDIKTI for Indonesian-German Center for Nano and Quantum Technologies (IG-Nano). B. Yuliarto and H.S. Wasisto thank the Directorate General of Higher Education, Science, and Technology Resources (Ditjen SDID), RISTEKDIKTI for providing them an opportunity to be involved in an excellent Indonesian diaspora platform of World-Class Scholar Symposium [Simposium Cendekia Kelas Dunia (SCKD)], which has led to establishment of continuous collaboration between domestic and diaspora scientists for accelerating transfer of science and technology and advancing research and development in Indonesia, especially in the fields of nanotechnology and sensors.’}, {‘$’: ‘This work is partially supported by the Ministry of Education and Culture and Ministry of Research and Technology under the grant scheme of the World Class University (WCU) Program managed by Institut Teknologi Bandung. Authors also acknowledge finance support from Institut Teknologi Bandung, Indonesia, and research grant from the Ministry of Education and Culture and Ministry of Research and Technology of Republic of Indonesia. H.S. Wasisto acknowledges the financial support from Lower Saxony Ministry for Science and Culture (N-MWK) for LENA-OptoSense group and RISTEKDIKTI for Indonesian-German Center for Nano and Quantum Technologies (IG-Nano). B. Yuliarto and H.S. Wasisto thank the Directorate General of Higher Education, Science, and Technology Resources (Ditjen SDID), RISTEKDIKTI for providing them an opportunity to be involved in an excellent Indonesian diaspora platform of World-Class Scholar Symposium [Simposium Cendekia Kelas Dunia (SCKD)], which has led to establishment of continuous collaboration between domestic and diaspora scientists for accelerating transfer of science and technology and advancing research and development in Indonesia, especially in the fields of nanotechnology and sensors.’}][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.1007/s10854-020-04102-2[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]