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Antibacterial activity of several indonesian plant extracts and combination of antibiotics with syzygium malaccense extract as the most active substance
Yuniarni U.a,b, Sukandar E.Y.a, Fidrianny I.a
a Department of Pharmacology-Clinical Pharmacy, School of Pharmacy, Bandung Institute of Technology, Bandung, 40132, Indonesia
b Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Bandung Islamic University, Bandung, 40116, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2020, J. K. Welfare and Pharmascope Foundation. All rights reserved.Natural products have an important role in the development of drugs, especially as an antibacterial. Some plant extracts in Indonesia such as Syzygium (Myrtaceae) and Graptophyllum (Acanthaceae) have been used empirically for the treatment of non-infectious diseases, and are also for management infections such as throat, mouth and vaginal infections, dysentery and diarrhea. The objectives of this study are to investigate antibacterial activity of 11 extracts from ten plants which were used in traditional medicine in Indonesia to treat infection disease and to evaluate interaction between potential antibacterial extract and antibiotics. Antibacterial activity and combination extract with antibiotics were evaluated using agar diffusion method on Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa. Among the ten plants, Syzygium malaccense leaves extract, and Nephelium lappaceum peel and leaves extracts showed signiicant antibacterial activity. They have antibacterial activity against Gram positive and Gram negative. S. malaccense extract had better antibacterial activity against P. aeruginosa compared to the other tested bacteria and provided better activity compared to N. lappaceum leaves extract. Phytochemical screening showed that S. malaccense leaves extract contained lavonoid, tannin, quinone, phenol and triterpenoid/steroid. The combination of S. malaccense extract with antibiotics showed that the usage of S. malaccense extract together with ciproloxacin gave antagonistic result, so the usage of S. malaccense extract together with ciproloxacin needs caution because it can reduce the effect of ciproloxacin.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Antibacterial,Antibiotics,Combination,Syzygium malaccense[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][{‘$’: ‘We would like to thank the Ministry of Research, Technology and Higher Education of the Republic of Indonesia and Indonesia Endowment Fund for Education (LPDP) for the funding and supporting on this research through the Indonesian Lecturer Excellence Scholarship (BUDI DN). Funding Support None Conৎlict Of Interest The authors declare no conϑlict of interest.’}, {‘$’: ‘We would like to thank the Ministry of Research, Technology and Higher Education of the Republic of Indonesia and Indonesia Endowment Fund for Education (LPDP) for the funding and supporting on this research through the Indonesian Lecturer Excellence Scholarship (BUDI DN).’}][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.26452/ijrps.v11i3.2456[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]