[vc_empty_space][vc_empty_space]
Inhibition of HUVECs proliferation and cytotoxic activities of xanthone derivatives from Garcinia mangostana
Hermawati E.a, Juliawaty L.D.a, Hakim E.H.a, Kinoshita K.b, Fukai M.b, Takahashi K.b, Koyama K.b
a Natural Product Research Group, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung, 40132, Indonesia
b Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Kiyose-shi, Tokyo, 204-8588, Japan
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2020 World Research Association. All rights reserved.Six known xanthones, α-mangostin (1), β-mangostin (2), γ-mangostin (3), 8-deoxygartanin (4), gartanin (5) and 9-hydroxycalabaxanthone (6) have been isolated from the CHCl3 extract of the pericarps of Garcinia mangostana (Guttiferae). Structures of these compounds were determined based on spectrocopic data. Evaluation of inhibitory effects of the isolated compounds on proliferation of Human Umbellical Vein Endothelial Cells (HUVECs) revealed that β-mangostin (2) is the most active compound with its IC50 value less than 1.0 µg/mL. Preliminary cytotoxic test against P-388 cells showed that gartanin (5) was the most active component with IC50 value at 1.3 μg/mL.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Garcinia mangostana,HUVECs,P-388 cells,Xanthone[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]The authors are grateful for the financial support from Japan Society for Promotion Science (JSPS) AA Scientific Platform Program.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]