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Analysis method of anti-cancer drug semustine for chemotherapy by cyclic voltammetry
Deswatia, Suyani H.a, Zein R.a, Pardi H.b, Bucharic, Setiyanto H.c
a Department of Chemistry, Faculty Mathematics and Natural Sciences of Andalas University, Padang, 25163, Indonesia
b Department of Chemistry Education, Faculty of Teacher Training and Education, Raja Ali Haji Maritime University, Tanjungpinang, 29111, Indonesia
c Department of Chemistry, Faculty Mathematics and Natural Sciences, Bandung Institute Technology, Bandung, 40132, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© RASĀYAN. All rights reserved.Alkylating compounds (melfalan, chlorambucyl, lomustine, and semustine) are chemical compounds commonly used for the treatment of chemotherapy and used as anti-cancer drugs. This is due to its reactivity in stopping the growth of cancer cells by directly reacting to the nucleophile centers of the DNA base. The alkylating compound attacks the target non-selectively, therefore it can attack healthy cells so that it can cause secondary cancer. Because of the hazardous nature of the alkylating compounds which can form secondary cancers, an analytical method for the anti-cancer drug semustine that has been circulating on the market by cyclic voltammetry has been developed. The objectives of this study are (1) to obtain the working stress area for the semustine compound in a water solvent, (2) to determine the effect of using variations of supporting electrolytes and working electrodes on the semustine voltammogram profile. Before the analysis of semustine is made, Ag/AgCl comparison electrodes are made by electrolysis, then the results are characterized using K3Fe(CN)6 in various supporting electrolytes including KCl, KNO3, and K2SO4. Subsequent research studied the effect of using variations of supporting electrolytes and working electrodes to measure the peak current of the anode and the cathode semustin and the voltammogram profile. The results provide information that KCl was used Pt as a working electrode, gives the highest peak current to the measurements of K3Fe(CN)6 were compared to K2SO4 and KNO3 on 9.091 mg/L semustine.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Anti-cancer Drug,Cyclic Voltammetry,Semustine[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]The authors thanks the Directorate of Research and Community Service (DRPM) for funding this research, through the National Competitive Grant Scheme In accordance with Research Contract Number: 051/SP2H/LT/DRPM/2019.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.31788/RJC.2020.1345845[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]