2-s2.0-85091561002

[vc_empty_space][vc_empty_space]

[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© RJPT All right reserved.Sodium ascorbyl phosphate (SAP) nanoemulsion has been developed using several methods with the aim of improving its skin permeation by transcutaneous delivery. SAP is a hydrophilic derivate of ascorbic acid with low permeability. Development of the formulation began with the utilization of glycerin as the solvent as well as co-surfactants, combined with the addition of amphiphilic molecules and lipophilic surfactants. Amphiphilic molecules and lipophilic surfactants formed complexes and emulsion, respectively, then underwent colyophilization prior to incorporating the lyophilizate to form nanoemulsion. Polyethylene glycol (PEG) 20000 and lecithin were used as the amphiphilic molecules, while Span 80 was employed as lipophilic surfactants. These methods aimed to improve the permeability of SAP, thus enhancing its permeation across the stratum corneum. The highest SAP solubility was achieved by adding 10% glycerin, which meant the glycerin could be used to increase the lipophilicity of SAP in the formulation. The amount of SAP partitioned into the oil phase was mixed by solid-in-oil dispersion (SOD) with PEG 20000, lecithin, and Span 80 was determined indirectly by measuring the concentration of SAP in the aqueous phase. The globule sizes of the SAP-PEG 20000 and SAPlecithin nanoemulsions were 50–200nm and > 500nm for the SAP-Span 80 nanoemulsion. The amount of diffused SAP was varied in an in vitro permeation study using the Franz diffusion cell, snake skin (Python R.) and Spangler’s as a membrane models. This study indicates that SAP could penetrate in to the skin by SOD method and its potential utility to improve the skin permeation of hydrophilic molecules.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Amphiphilic,Lyophilization,Nanoemulsion,Permeation,Sodium ascorbyl phosphate[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]This research was supported by a a research grant from Bandung Institute of Technology (2015) and doctoral dissertation grant from the Ministry of Research, Technology and Higher Education of Indonesia (2016).[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.5958/0974-360X.2020.00547.8[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]