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Fabrication of fe3O4 nanoparticles coated with dimethylaminobenzyl-Chitosan
Pura M.a, Wibowo A.a, Ardy H.a, Purwasasmita B.S.a
a Materials Science and Engineering Research Group, Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2020 American Institute of Physics Inc.. All rights reserved.Alzheimer is one of degenerative disease that slowly destroys memory and cognitive ability. Currently, magnetic resonance imaging (MRI) technique combined with contrast agent is widely used to detect this disease at early stage because MRI offer better safety for patient with zero long term risk. To obtain accurate result, it is favorable that contrast agent has ability to accumulate effectively in the brain tissue that has been affected by Alzheimer. One of strategy to increase their target ability is by adding ß-amyloid protein binding ligand in the surface of contrast agent because brain tissue has ß-amyloid protein that can be used as targeting site in Alzheimer site. In this study, iron oxide nanoparticles were prepared by sol gel method, and coated with chitosan that already modified with Dimethylaminobenzyl to increase their attachment to ß-amyloid protein. Transmission Electron Microscopy (TEM) image confirm that iron oxide nanoparticles with particle size 12 ± 4 nm were formed. TEM image also revealed that the particle was surrounded by corona with thickness around 6 nm, which is most likely correlated with end-to-end distance of chitosan.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]The authors would like to acknowledge the funding provided by Basic Research Fund from Indonesian Ministry for Research, Technology and Higher Education 2019.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.1063/5.0015732[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]