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Development and characterization of self-nanoemulsifying drug delivery system (Snedds) formulation for enhancing dissolution of fenofibric acid
Suhery W.N.a,b, Sumirtapura Y.C.a, Pamudji J.S.a, Mudhakir D.a
a School of Pharmacy, Institut Teknologi Bandung, Bandung, 40132, Indonesia
b Sekolah Tinggi Ilmu Farmasi Riau (STIFAR), Pekanbaru, 28293, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2020 Marmara University Press.Fenofibric acid is an active form of fenofibrate and a poorly water-soluble drug. The study aims to formulate and characterize self-nanoemulsifying drug delivery system (SNEDDS) to improve the dissolution of fenofibric acid. The selection of oil, surfactant, and cosurfactant for preliminary screening was determined by the solubility study of fenofibric acid in various vehicles. The composition of selected oil, surfactant, and cosurfactant was glyceryl monolinoleate (Maisine® CC), Kolliphor® RH 40, and Transcutol® HP, PEG 400 respectively. The study results showed that the best SNEDDS formulation was Fd with a ratio of oil, surfactant, and cosurfactant of 10:70:20 % v/v/v (Maisine® CC: Kolliphor® RH 40: Transcutol® HP). It produced good self-nanoemulsifying drug delivery system such as the droplet size was 15.30 nm, 99.27 % transmittance, thermodynamically stable, self-emulsification time was 18.84 seconds, the morphology of the formed nanoemulsion droplets was observed as sphere-shaped droplets and 1.6 fold increase in the dissolution of fenofibric acid.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Dissolution,Fenofibric acid,Long-chain triglyceride,Maisine® CC,SNEDDS[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]Acknowledgements: This work was supported by the Institute for Research and Community Services of Institut Teknologi Bandung (ITB), Indonesia under Grant of Research, Community Services, and Innovation (P3MI) Program (no. 902b/SK/l1.C03/PL/2018).[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.35333/jrp.2020.227[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]