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Antidiabetes activity of herbal product containing phyllanthus Niruri and Zingiber Americans Aktiviti antidiabetes produk herba yang mengandungi phyllanthus niruri dan zingiber americans
Elfahmia, Ketut Adnyana I.a, Fitria I.a, Taufikurahman T.a
a School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2020 Penerbit Universiti Kebangsaan Malaysia. All rights reserved.state of hyperglycemia which usually accompanied by increasing blood glucose level. The combination of Phyllanthus niruri herbs and Zingiber americans rhizome has been produced as herbal medicine for the treatment of diabetes. The activity of herbal medicine product containing P. niruri and Z. americans in vivo. Antidiabetes activity was tested using oral glucose tolerance and alloxan induced methods. The blood glucose levels were measured in each experiment. In addition, the plasma triglyceride and total cholesterol levels were also measured. The results showed that the decrease of blood glucose levels on oral glucose tolerance method were 40.98, 44.84, and 47.02% at doses of 90, 135, and 203 mg/kg BW, respectively (p <0.05) compared to control. While the decrease in blood glucose levels in alloxan induced method were 33.05, 38.82, and 41.79% at dose 90, 135, and 203 mg/kg BW, respectively (p <0.05) compared to control. The extract of dose 203 mg/kg BW appeared to be the most potent to decrease blood glucose levels in both methods, but did not show suppression activity of triglycerides and total cholesterol plasma. Suppression activities of serum triglycerides and total cholesterol were shown after treatment with the extract dose 90 and 135 mg/kg BW, which were each were 0.15, 0.16, and 1.85% w/w, respectively.[/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Author keywords" size="size-sm" text_align="text-left"][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Indexed keywords" size="size-sm" text_align="text-left"][vc_column_text]Diabetes,Herbal medicines,Jamu,Phyllanthus niruri,Zingiber americans[/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Funding details" size="size-sm" text_align="text-left"][vc_column_text]The authors would like to acknowledge the Ministry of Research & Technology and Higher Education for financial support through the community services program. Thanks for CV Dewa Honey, Depok, eW st ava, Indonesia who donate the herbal medicines product.[/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="DOI" size="size-sm" text_align="text-left"][vc_column_text]https://doi.org/10.17576/jsm-2020-4909-14[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]