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Synthesis of self-assembled hydroxyapatite membrane using bio-template with surface modification
Daulay A.H.a, Nathisa I.b, Purwasasmita B.S.b
a Physics Department, Universitas Islam Negeri Sumatera Utara, Medan, Indonesia
b Materials Engineering Study Program, Bandung Institute of Technology, Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2018 Society for Innovative Research. All rights reserved.Many researches in tissue engineering have been conducted continuously to develop the proper synthetic materials for tissue and organ substitute materials. At this research, the synthesis of hydroxyapatite membrane for bone scaffold application has been done successfully by self assembly method using eggshell membrane with surface modification as a template. By this method, the pores obtained will be able to resemble the cells microenvironment thus can enhance interface interaction and support cell proliferation. Before incubating in modified Simulated Body Fluid (SBF) Kokubo solution, eggshell membrane surface is modified using alginate and chitosan solutions to increase the number of hydroxyapatite particles bonded due to enhance the bioactivity of scaffold. The Scanning Electron Microscopy (SEM) result showed that hydroxyapatite membrane has been formed on scaffold’s surface where the diameter of fibers had thickened to 2.035, 2.591 and 1.408 μm and particle size of 1.021, 0.934 and 0.895 μm for 6, 9 and 12 days incubation time respectively. It confirmed that the number of hydroxyapatite grown increases along with the incubation time. These results are in good agreement with FT-IR analysis that indicates the presence of PO43- functional group on the scaffolds.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Eggshell membrane,Hydroxyapatite,Scaffold,Self assembly,simulated body fluid[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]