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Diffusion and Interaction between ion Ca2+ and ion Gd3+ in a Model Synapse: A Monte Carlo Study
Sutresno A.a,b, Haryanto F.a, Viridi S.a, Arif I.a
a Nuclear Physics and Biophysics Research Group, Physics Department, Institut Teknologi Bandung, Bandung, 40132, Indonesia
b Physics Department, Faculty of Science and Mathematics, Satya Wacana Christian University, Salatiga, 50711, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© Published under licence by IOP Publishing Ltd.Gadolinium (Gd3+) is a commonly used in MRI. The role of Gd3+ as contrast agent greatly helps to improve the quality of an image and Gadolinium entrance in a body through a diffusion process after administration. Diffusion process takes place from outside pre-synapse to inside pre-synapse through Ca2+ channels. This process causes a delay of Ca2+ in passing Ca2+ channels to pre-synapse. This study aims to determine equilibrium concentration of Ca2+ and Gd3+ so that Ca2+ can pass Ca2+ channels. To address the effect of Gd3+ concentration around Ca2+ channels, we developed a Monte Carlo simulation on Ca diffusion and interaction with Gd. We find Gd3+ concentration in a certain threshold can be potential as a blocker Ca2+ diffuse entrance into pre-synapse. In another hand, an amount of Ca2+ channels and pre-synapse terminal to continuing diffusion of vesicles to clef was important. And the trapping Gd3+ in pre-synapse effects in diffusion delays also. These simulations identify characteristics of the interaction between Ca2+ and Gd3+ in Ca channels which entrance into pre-synapse through diffusion process depend on concentration with each other.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Contrast agent,Diffusion delays,Diffusion process,Equilibrium concentration,Synapse[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Contras Agents,Diffusion,Monte Carlo Cell,Synapse[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]This work is partially supported by Grant of PDD 2017 (001/K6/KM/SP2H/PENELITIAN/2017) and Grant of PUPT 2017 (009/SP2H/LT/DRPM/IV/2017) from Ministry of Research, Technology and Higher Education[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.1088/1742-6596/1127/1/012006[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]