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Investigation of diffusion process inside the cell using Monte Carlo Cell (MCell)
Sutresno A.a,b, Haryanto F.a, Viridi S.a, Arif I.a
a Department of Physics, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung, 40132, Indonesia
b Department of Physics, Faculty of Mathematics and Natural Sciences, Satya Wacana Christian Univeristy, Salatiga, 50711, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© Published under licence by IOP Publishing Ltd.Understanding a structure, function and molecular mechanisms of a cell are not easy. Even though, it is difficult, but it still has a solution to be investigated. The aim of this study is to investigate the compartment model as a structure of a cell and diffusion process inside a cell and nucleus by using Monte Carlo simulation. MCell was used to analyze the compartment model for mechanisms inside a cell and nucleus. Compartment model consist two icosphere with different size, with cell diameter for 0.8 μm and nucleus diameter varies for about 0.4, 0.5, and 6 μm, respectively. Another parameter was their width and a model of receptor on the surface of the nucleus. During investigation, an amount of receptor was 120, 150, and 180 grid element. The model was collected and separated. The diffusion process flew from cell to the nucleus and returned to the cell with 2000 molecules on surface. MCell successfully simulated compartment model for a cell and the nucleus. Diffusion process depended on the diameter of the nucleus. The greater the nucleus, more effective the speed of diffusion process would be because the concentration inside the cell was increase and concentration in the nucleus was decrease.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Cell diameters,Compartment model,Different sizes,Diffusion process,Grid elements,Molecular mechanism,Nucleus diameter[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]This work is partially supported by ITB and JICA 2015 and thanks to Nagai Group at Osaka University for support Mouse cell visible.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.1088/1742-6596/694/1/012077[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]