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Antihyperuricemic and xanthine oxidase inhibitory activities of fractions from ethanolic leaves extract of Stelechocarpus burahol
Sunarni T.a,b, Leviana F.b, Fidrianny I.a, Immaculata M.a, Wirasutisna K.R.a
a Pharmaceutical Biology Reseacrh Group, School of Pharmacy, Bandung Institute of Technology, Indonesia
b Department of Pharmaceutical Biology, Faculty of Pharmacy, Setia Budi University, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2016 The Authors. Published by Innovare Academic Sciences Pvt Ltd.Objective: The aims of the research were to evaluate antihyperuricemic and xanthine oxidase (XO) inhibitory activity of fractions from ethanolic leaves extract of Stelechocarpus burahol. Methods: S. burahol leaves powder was extracted in ethanol by maceration method, then extract was fractionated by liquid-liquid extraction method using n-hexane and ethyl acetate. Hyperuricemic rat model was induced by administered potassium oxonate intraperitoneally. The activity of these fractions on XO inhibitory was determined by measuring the uric acid (UA) formation using ultraviolet-visible spectrophotometry method after incubating with XO. Results: The n-hexane and ethyl acetate fractions significantly (p<0.05) reduce the uric level by 32.0% and 28.0% respectively compared to UA level of hyperuricemic group at 1 hr after drug administration (p<0.05). On XO inhibitory activity test, only n-hexane fraction exhibited poor XO inhibitory activity. Conclusion: The n-hexane and ethyl acetate fractions from ethanolic leaves extract of S. burahol had antihiperuricemic activity, but less inhibitor effect on XO activity.[/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Author keywords" size="size-sm" text_align="text-left"][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Indexed keywords" size="size-sm" text_align="text-left"][vc_column_text]Antihyperuricemic,Liquid-liquid extraction,Stelechocarpus burahol,Xanthine oxidase inhibitory activity[/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Funding details" size="size-sm" text_align="text-left"][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="DOI" size="size-sm" text_align="text-left"][vc_column_text]https://doi.org/10.22159/ajpcr.2016.v9i6.14314[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]