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The study of antifungal activity from indigenous plants from indonesia: An in vitro study
Sukandar E.Y.a, Fidrianny I.b, Susanto E.a, Safitri D.a
a Pharmacology and Clinical Pharmacy Research Group, Indonesia
b Pharmaceutical Biology Research Group, School of Pharmacy, Institut Teknologi Bandung, Bandung, 40132, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2017 The Authors.Objective: This study aimed to analyze new agents from extracted Indonesia herbs possessing antifungal activity with better safety profile against Candida albicans, Microsporum gypseum, and Trichophyton mentagrophytes. Methods: The screening of 11 herbs was performed to determine the highest antifungal activity. Minimum inhibitory concentration and minimum fungicidal concentration of selected extracts, rosemary (Rosmarinus officinalis) leaves, java turmeric (Curcuma xanthorrhiza) rhizome, and ginger (Zingiber officinale) rhizome were determined using microdilution and agar diffusion methods. Extracts were then combined to evaluate further activities. Selected extracts were fractionated using liquid-liquid extraction, analyzed by thin-layer chromatography-direct (TLC) bioautography. Results: Ethanolic extract of rosemary (R. officinalis) leaves, java turmeric (C. xanthorrihza) rhizome, and ginger (Z. officinalis) rhizome in combination showed the highest activity and synergistic interaction against Trichophyton mentagrophytes. There were several components from fractions that actively inhibited corresponding fungi according to TLC bioautography method. Conclusion: Ethanolic extracts of rosemary, java turmeric, and ginger had the highest antifungal potency, both as extract and in combination comparable to ketoconazole as reference drug. These selected extracts are potential to be used as new antifungal agents.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Antifungal,Bioautography thin-layer chromatography-direct,Ginger,In situ,Java turmeric,Rosemary[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.22159/ajpcr.2017.v10i1.14838[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]