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The study of ethanolic extract of binahong leaves (Anredera cordifolia [Ten.] Steenis) and mulberry leaves (Morus nigra L.) in combination on hyperlipidemic-induced rats
Sukandar E.Y.a, Safitri D.a, Aini N.N.a
a Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Institute Teknologi Bandung, Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2016 The Authors. Published by Innovare Academic Sciences Pvt Ltd.Objective: This study aimed to determine the antihyperlipidemic activity of binahong leaves and murbey leaves extracts in combination. Methods: A total of 28 rats were divided into seven groups: normal, control, simvastatin 3.6 mg/kg bw, binahong leaves extract 100 mg/kg bw (B100), mulberry leaves extract 200 mg/kg bw (M200), combination of binahong extract 50 mg/kg and mulberry 100 mg/kg (B50+M100), and combination of binahong extract 100 mg/kg bw and mulberry 200 mg/kg bw (B100+M200). Hyperlipidemia was induced by giving rats a high-fat diet along with cholesterol (200 mg/kg), cholic acid (0.2% of chow), and propylthiouracil (10 mg/kg bw) for 30 days orally. Then, for the next 14 days, all groups except the control were given the tested substances. Measurement of lipid profile was performed immediately after induction (T0), 7 and 14 days after treatment (T7 and T14, respectively). Results: There were significant differences on a group of M200, B50+M100, and B100+M200 compared to the control group at T14, with the value 33.68%, 34.39 %, and 44.81% (in reduction of total cholesterol [TC]) and 36.86%, 37.16%, and 49.99%, respectively (in reduction of triglyceride [TG]). Conclusion: Group of M200, B50+M100, and B100+M200 reduced TC and TG level remarkably at day 14. The combination of both extract (B100+M200) considerably shows better activity than either binahong extract or mulberry extract.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Anredera cordifolia,Antihyperlipidemia,Binahong,Morus nigra,Murbey[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.22159/ajpcr.2016.v9i6.14412[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]