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Anti-dysentery activity of tetracycline in combination with Curcuma xanthorrhiza Roxb. or Sonchus arvensis L
Sukandar E.Y.a, Kurniati N.F.a, Purnama A.B.a
a Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Institute of Technology Bandung, Jawa Barat, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2016 The Authors. Published by Innovare Academic Sciences Pvt Ltd.Background: Bacterial dysentery, diarrhea caused by Shigella sp. infection, causes a major morbidity and mortality in rural communities of developing countries. In Indonesia, most of the dysentery patients often use antibiotics in combination with herbal medicine to enhance the effect. Objective: This research aimed to examine the effect of tetracycline in combination with Curcuma xanthorrhiza Roxb. or Sonchus arvensis L. as an anti-dysentery. Methods: Antibacterial activity of each extract against Shigella flexneri was determined using microdilution method. Furthermore, its activity in combination with tetracycline was determined using checkerboard method. To assess its effect in in vivo, the drug combination was given orally into S. flexneri-infected rat for 7 consecutive days and total plate count in the feces of the rats was determined. Results: The minimum inhibitory concentration (MIC) of tetracycline, the ethanol extract of C. xanthorrhiza and S. arvensis against S. flexneri was 4, 128, and 512 mg/100 μL, respectively. The combination of each extract with tetracycline could reduce their MIC value, but the total MIC was not lower than 0.5, suggesting an additive interaction. However, in in vivo study, both combinations could reduce the number of bacteria found in the feces of the rat significantly compared to positive control and to tetracycline only-treated rat at day 6 after administration of the drug, suggesting a synergistic interaction. Conclusion: A combination of tetracycline with ethanol extract of C. xanthorrhiza or with S. arvensis is potential to be developed as anti-dysentery drugs against S. flexneri.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Curcuma xanthorrhiza,Dysentery,Sonchus arvensis,Tetracycline[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.22159/ajpcr.2016.v9i6.14033[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]