[vc_empty_space][vc_empty_space]
Safety of garlic (allium sativum) and turmeric (curcuma domestica) extract in comparison with simvastatin on improving lipid profile in dyslipidemia patients
Sukandar E.Y.a, Sudjana P.b, Sigit J.I.a, Leliqia N.P.E.a, Lestari F.a
a School of Pharmacy, Bandung Institute of Technology, Indonesia
b Hasan Sadikin Hospital, Bandung, Teaching Hospital of University, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Dyslipidemia is the major cause of atherosclerosis. A number of drugs that inhibit cholesterol synthesis has indicated to control lipid profile. However, these lipid lowering drugs are not free of side effect. Therefore a substance that less toxic and yet effective would be beneficial. Here we compared the anticholesterol effect of combination of garlic and turmeric extract, a herbal product, with a standard lipid lowering drug, simvastatin. Thirty nine people were recruited and randomized into two groups, Garlic-Turmeric (G-T) group (n = 19) received three times two capsules of garlic-turmeric extract (2.4 g day-1) and simvastatin group (n = 20) received placebo and 5 mg simvastatin to blind the subjects from knowing what drugs they get, for 14 weeks. Garlic-turmeric extract could improve lipid profile comparable with simvastatin (p = 0.366). There were no adverse event related to garlic-turmeric administration, even there was improvement in liver function at the end of the study. In conclusion garlic-turmeric extract could improve lipid profile comparable to simvastatin with no significant adverse event.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Adverse events,Dyslipidemia,Garlic,Turmeric[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.3923/jms.2013.10.18[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]