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In Vitro evaluation of xanthine oxidase inhibitory activity of selected medicinal plants
Hendriani R.a,b, Sukandar E.Y.a, Anggadiredja K.a, Sukrasnoa
a School of Pharmacy, Bandung Institute of Technology, Indonesia
b Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2016, International Journal of Pharmaceutical and Clinical Research. All rights reserved.The objective of this study was to investigate natural herbals that can be developed to help treat gout. Gout is a painful joint inflammatory disease caused by a buildup of uric acid in the joint tissues whose production is catalyzed by xanthine oxidase. The study began with the screening of several plants which are used empirically to treat gout in Indonesia. The screened plant parts were Mimosa pudica Linn. herbs, Orthosiphon stamineus Benth leaves, Sonchus arvensis L. leaves, Andrographis paniculata (Burn.f.) Nees leaves, Centella asiatica (L) Urban herbs, Catharanthus roseus leaves, Sida rhombifolia L. stems, Physalis peruviana leaves, Tinospora crispa (L.) Miers stems, Anredera cordifolia (Ten.) Steenis. herbs, Annona muricata L. leaves and Imperata cyllindrica stems. Activity tests were conducted in vitro by measuring the activity of the enzyme xanthine oxidase using UV spectrophotometry. Results showed the ethanol extracts S. rhombifolia stems showed the highest inhibition on xanthine oxidase activity with IC50 of 21.43 µg/mL, followed by S. Arvensis leaves extract with IC50 of 23.64 µg/mL. The xanthine oxidase inhibitory potential and IC50 values of the other extracts are also reported. Results of the present study suggest the potential use of S. rhombifolia and S. Arvensis extracts in the therapy of hyperucemia and gout.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Gout,Medicinal plants,Xanthine oxidase inhibitor[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]