2-s2.0-85090516862

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[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© RASĀYAN. All rights reserved.Sonchus arvensis (Linn) was empirically used for the treatment of hypertension. The extract has a good effect on reducing blood pressure. The compound in S. arvensis, a role in controlling the blood pressure still unknown. This experiment evaluated the antihypertension activity of the compound from S. arvensis dependent on the polarity of the compound. Evaluation of blood pressure was carried out using rats with a tail-cuff method, and the mechanism evaluated using the frog’s heart by observing changes in cardiac contraction. Epinephrine was used as acute inducer hypertension. The result showed that polar and nonpolar compounds did not show antihypertension activity, it was characterized by high of the systolic and diastolic blood pressure, and the semi-polar fraction contains semi-polar compounds were able to inhibit epinephrine-induced hypertension. The result showed that the dose of 16 mg/kg could prevent as much as 68.24% and 58.56% of the elevating systolic and diastolic blood pressure. This Result equivalent to atenolol 4.5 mg/kg as a beta-receptors antagonist. The effect was correlated to the lowered impact on heart rate in the ex vivo method. The suggested potential mechanism is blocking the beta-receptor in cardiomyocyte, and blood pressure can be decreased because of reducing cardiac output and heart contraction. Semi-polar fraction collected by ethyl acetate as solvent. That fraction was rich in flavonoid and phenol compounds than other fractions. One of the compounds that characterized in the semi-polar fraction is luteolin. It is the potential candidate who has acted as antihypertension.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Flavonoids,Hypertension,Luteolin,Polarity,S. arvensis[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]This study is part of doctoral program research. We thank the Directorate General of Higher Education of Education Ministry of Republik Indonesia for its financial support. The name of the grant is Pendidikan Magister Sarjana Doktor Unggulan Batch II-2015, grant number 134/SP2H/LT/DRPM/IV/2017 and also thank Department of Pharmacology, Faculty of Pharmacy, University of Jenderal Achmad Yani, Cimahi, Indonesia, which allowed us to work and assisted us in using KENT Scientific CODA’s System instrument at the Laboratory of Pharmacology.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.31788/RJC.2020.1335843[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]