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Pharmacological screening for potency of antiobesity on five plants based on ethnopharmacological use
Setiawan F.a,b, Ketut Adnyana I.a, Sukandar E.Y.a, Sukrasnoa, Yuniarto A.a, Pebritrinasari R.a
a Pharmacology and Clinical Pharmacy Research Group, School of Pharmacy, Bandung Institute of Technology, Bandung, 40132, Indonesia
b University of Surabaya, Surabaya, East Java, 60293, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2015, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.Objective: The objective of this research was to screening potency of anti-obesity effect and antioxidant activity from Sapindus rarak Pulp., Punica granatum Leaves, Jasminllum sambac Flos., Tamarindus indica Pulp., and Senna alexandrina Leaves. Methods: This study was performed through in-vitro method to determine the potency of anti-obesity, such as its ability to inhibit pancreatic lipase activity and radical-scavenging activity against free radicals like 1,1-diphenyl-2-picrylhydrazyl to determine the potency of these plants as antioxidant. Results: The 50% inhibitory concentration of pancreatic lipase activity inhibitory and antioxidant activity consecutively, P. granatum Leaves (20.64 ppm; 77.89 ppm), J. sambac Flos. (53.46 ppm; 127.95 ppm), T. indica Pulp. (62.02 ppm; 159.16 ppm), S. alexandrina Leaves (94.69 ppm; 142.28 ppm), and S. rarak Pulp. (796.32 ppm; 147.56 ppm). Conclusion: P. granatum Leaves showed the best potency of anti-obesity compared to other plants based on its ability to inhibit pancreatic lipase activity and antioxidant activity.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Anti-obesity,Antioxidant,Pancreatic lipase activity[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]