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5,6-Dihydro-α-pyrones from the leaves of Cryptocarya pulchinervia (Lauraceae)
Juliawaty L.D.a, Ra’idah P.N.a, Abdurrahman S.a, Hermawati E.a, Alni A.a, Tan M.I.a, Ishikawa H.b, Syah Y.M.a
a Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung, 40132, Indonesia
b Department of Chemistry, Kumamoto University, Kumamoto, 860-8555, Japan
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2020, The Japanese Society of Pharmacognosy.Three new 5,6-dihydro-α-pyrones derivatives, named (S)-rugulactone (1) pulchrinervialactone A (2), and pulchrinervialactone B (4), along with one known pyrone, cryptobrachytone C (3), and three known amide derivatives (5–7) have been isolated from the leaves of Cryptocarya pulchrinervia. The structures of 1–7 were elucidated based on extensive spectroscopic data and comparison with literatures. The configurations of compounds 3 and 4 were established by single crystal X-ray diffraction analysis. This is also the first report in finding (S)-rugulactone (1) as a natural product. In addition, the preliminary cytotoxic activity of the isolated compounds was evaluated against P-388 cells using the [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. All the pyrones, except compound 4, were active significantly inhibiting the growth of P-388 cells, while the amides derivatives (5–7) showed moderate to weak activities. Therefore, compounds 1–3 could be potentially examined further for anticancer agents.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Animals,Antineoplastic Agents,Cell Line, Tumor,Cell Proliferation,Cryptocarya,Lactones,Mice,Molecular Structure,Neoplasms,Plant Leaves,Pyrones[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text](S)-rugulactone,Cryptobrachitone C,Cryptocarya pulchrinervia,P-388 cells,Pulchrinervialactone A,Pulchrinervialactone B[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][{‘$’: ‘We acknowledge the Research Grant of Penelitian Dasar Unggulan Perguruan Tinggi (PDUPT) 2017 from Ministry of Research, Technology and Higher Education of the Republic of Indonesia, for part of financial support to this research, and also Bogor Botanical Garden, Center for Plant Conservation, Indonesian Institute of Sciences, Bogor, West Java, Indonesia for collecting and identifying the plant sample.’}, {‘$’: ‘We acknowledge the Research Grant of Penelitian Dasar Unggulan Perguruan Tinggi (PDUPT) 2017 from Ministry of Research, Technology and Higher Education of the Republic of Indonesia, for part of financial support to this research, and also Bogor Botanical Garden, Center for Plant Conservation, Indonesian Institute of Sciences, Bogor, West Java, Indonesia for collecting and identifying the plant sample.’}][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.1007/s11418-020-01397-7[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]