[vc_empty_space][vc_empty_space]
The study of red ginger Rhizomes ethanol extract (Zingiber Officinale Roscoe Var. Sunti Val.) on hyperlipidemic-induced rats
Safitri D.a, Kurniati N.F.a, Adharani S.a, Suciyati S.W.a, Adnyana I.K.a
a School of Pharmacy, Bandung Institute of Technology (ITB), Bandung, 40132, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2016, SILAE (Italo-Latin American Society of Ethnomedicine). All rights reserved.One of the main causes of cardiovascular disease is hyperlipidemia, an elevation of lipid in the blood. Lipids are major components of atherogenic plaques and many studies have proven that lipids disrupt the structure and function of blood vessels by forming lipid layers in the endothelial wall. Therefore, hyperlipidemia is a risk factor for atherosclerosis. This study aims to determine activity of red ginger rhizomes ethanol extract (RGREE) in hyperlipidemic rats model. Hypercholesterolemic model was conducted in vivo in male SpragueDawley rats which were induced by administration of high-cholesterol diet, cholic acid, and propylthiouracil (PTU). Activity of the extract was evaluated by measuring lipid profile according to enzymatic reaction through UV spectrophotometry methods compared to simvastatin. Aorta from each rat was isolated and stained by Hematoxyllin-Eosine for further observation under optical microscope. Group treated with RGREE 100 mg/kg bw decreased the total cholesterol and triglyceride level by 15.83% ± 6.46% and 37.98% ± 54.99% also increased the HDL level by 7.52% ± 22.43%. Group treated with RGREE 400 mg/kg b. w. decreased the total cholesterol and triglyceride level by 25.51% ± 18.22% and 54.54% ± 32.72%, increased the HDL level by 33.93% ± 42.61%. Simvastatin treated group showed that there were reduction in term of total cholesterol and triglyceride level by 17.81% ± 12.66% and 49.17% ± 40.37% respectively. RGREE decrease total cholesterol level significantly compared to simvastatin.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Atherosclerosis,Hyperlipidemia,Red ginger,Simvastatin[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]