[vc_empty_space][vc_empty_space]
FTIR-derivative as a green method for simultaneous content determination of caffeine, paracetamol, and acetosal in a tablet compared to HPLC
Nugrahani I.a, Manosa E.Y.a, Chintya L.a
a School of Pharmacy, Bandung Institute of Technology, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2019This research developed and validated an alternative method for the simultaneous content determination of caffeine (CF), paracetamol (PCT), and acetosal (ACT) in a tablet dosage form using Fourrier transform infra red FTIR. First, the vibrational spectrometer measured the absorption spectra, and then the distinctive peak for quantification was selected, supported by derivatization. After a series of tests of the validation parameters, we then attempted to determine the contents of the drug. Then, a study comparing our results to those of HPLC, the method from the compendium, was performed. The observations revealed that each active ingredient has a different moiety so that FTIR can measure the specific level of each drug, and the vibrational spectroscopy fulfilled the validation requirement. Although this method showed lower sensitivity than the compendium method, it was still appropriate to determine the three drugs in a tablet. There was no significant difference in our result compared to the HPLC measurement. Moreover, this method exhibits some advantages such as being more rapid, straightforward, efficient, economical, and environmentally friendly. In conclusion, FTIR is suitable and adequate as an alternative for quantifying the common dose of CF-PCT-ACT in a tablet dosage form.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Acetosal,Content determination,FTIR,HPLC,Paracetamol[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Acetosal,Caffeine,Content-determination,FTIR,HPLC,Paracetamol[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][{‘$’: ‘This research was supported by Research Institute and Community Service of Bandung Institute of Technology, Indonesia, from the ?Capacity Improvement Research? Program Funding, 2018.’}, {‘$’: ‘This research was supported by Research Institute and Community Service of Bandung Institute of Technology , Indonesia, from the “Capacity Improvement Research” Program Funding, 2018.’}][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.1016/j.vibspec.2019.102941[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]