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Development of nanostructured lipid carrier formulation containing of retinyl palmitate
Pamudji J.S.a, Mauludin R.a, Indriani N.a
a School of Pharmacy, Institut Teknologi Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2016 The Authors. Published by Innovare Academic Sciences Pvt Ltd.Objective: The purpose of this research is to develop a Nanostructure Lipid Carrier (NLC) formulation containing of Retinyl Palmitate. Methods: Preparation of NLC was carried out by ultrasonication method. The formulas of NLC were developed by using virgin coconut oil and oleic acid as a liquid lipids, cetyl palmitate, and stearic acid as solid lipids, Tween 80 and Poloxamer as a surfactant and glycerine as co-surfactant. Characterization of NLC consisted of visual appearance, morphology, particle size, polydispersity index (PI), and physical stability test using freeze-thaw, centrifugation, and accelerate stability test method. Results: Obtained NLC revealed a good characterization with the formulation of 7.2% of cetyl palmitate, 4.8% of oleic acid, 10% of Tween 80, 10% of glycerin, and 2% of retinyl palmitate. This NLC has a pale yellow appearance, globule size of 258±15.85 nm; and a polydispersity index of 0.31±0.09. It was also physically stable after centrifuged at 13,000 rpm for 30 min, during 4 cycles of freeze-thaw and storage at room temperature for 28 d. During storage for 28 d, retinyl palmitate in NLC had been degraded only about 15% in comparison with macroemulsion destroyed almost 50% of retinyl palmitate in the same time. Conclusion: NLC formulations with 7.2% cetyl palmitate, 4.8% of oleic acid, 10% of Tween 80, 10% of glycerol, and 2% of retinyl palmitate is the most optimal formula that showed a good characteristic. Stability study revealed that NLC provided better stability than macroemulsion.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]NLC,Retinyl palmitate,Ultrasonication methode[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]