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Cytotoxic activities of prenylated flavonoids from Artocarpus heterophyllus
Musthapa I.a, Hakim E.H.b, Syah Y.M.b, Juliawaty L.D.b
a Organic Division, Chemistry Department, Universitas Pendidikan Indonesia, Jl. Dr. Setiabudhi Bandung, Indonesia
b Organic Division, Chemistry Department, Institut Teknologi Bandung, Jl. Ganeca, Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2006-2016 Asian Research Publishing Network (ARPN). All rights reserved.The methanol extract of the heartwood of Artocarpus heterophyllus were purified using several chromatography tehnique to give eleven flavonoid compunds: Gemichalcone A (1), gemichalcone B (2), norartocarpanone (3), artocarpanone (4), dihydromorin (5), norartocarpetin (6), artocarpesin (7),cycloartocarpesin (8), cudraflavone C (9), artocarpin (10), and cycloartocarpin (11). The structure of these compounds established by spectroscopic mean and by comparison with the literature values. Compound 10, exhibited very strong (IC50 < 2,0 μg/mL), whereas compounds 2 and 9 showed strong inhibition (IC50 2,1-4,0 μg/mL) against P-388 cell lines.[/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Author keywords" size="size-sm" text_align="text-left"][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Indexed keywords" size="size-sm" text_align="text-left"][vc_column_text]Artocarpus heterophyllus,Cytotoxic,Flavonoids[/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Funding details" size="size-sm" text_align="text-left"][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="DOI" size="size-sm" text_align="text-left"][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width="1/4"][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]