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Fast dissolving ibuprofen nanocrystalloaded solid dosage forms
Mauludin R.a,b, Moschwitzer J.b, Muller R.H.b
a School of Pharmacy, Bandung Institute of technology, Indonesia
b Department of Pharmaceutical Technology Biopharmaceutics and NutriCosmetics, Free University of Berlin, Germany
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Purpose: Many expensive formulation approaches are conducted to accelerate the dissolution velocity of ibuprofen for a faster performance. A very simple approach is the drug nanonization by high pressure homogenization (HPH), which leads to an accelerated dissolution velocity. In this study ibuprofen nanocrystals were produced by HPH incorporated into effervescent and pellet formulations. The properties of the final formulations have been tested with respect to redispersabilty, morphology and dissolution velocity. Methods: A formulation screening was carried out to ascertain the most suitable formulation for further processing. A Micron LAB 40 (APV Homogenizers, Unna, Germany) was used for the HPH. Photon correlation spectroscopy (PCS) (Malvern Zetasizer IV) and laser diffraction (LD) (Coulter LS 230) were employed to determine the particle size. The pellets were formed by extrusion and spheronization using an extruder Caleva Model 10 (Caleva, Sturminster Newton, UK) and a spheronizer Caleva Model 120 (Caleva, Sturminster Newton, UK). Dissolution test was performed with a Pharmatest PTW SIII (Pharma Test, Hamburg, Germany). Drug concentrations were determined using HPLC. Results: A suitable nanosuspension formulation could be found. After 40 homogenization cycles the size-average determined with PCS was 929 nm. A polydispersity index of 0.157, indicates a narrow size distribution. The volume size distribution showed that 50% (LD 50%) of the ibuprofen nanocrystals were smaller than 1.983 μm and 1.763 μm in diameter after redispersion. Pellets and effervescent powders were successfully produced. Ibuprofen nanocrystal could be redispersed completely from both formulations. Both formulations have shown a complete dissolution within 30 minutes in 0.1 N HCl-solution.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Dissolution,Effervescent,Ibuprofen,Nanocrystals,Nanosuspension,Pellet,Solubility[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]