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Antimicrobial and cytotoxic activities of Jatropha curcas Linn. seedcake from biofuel production
Ruslan K.a, Rukayadi Y.b, Wahyuningsih R.a, Singgih M.a, Elfahmia
a Pharmaceutical Biology Research Group, School of Pharmacy, Bandung Institute of Technology, Indonesia
b Biopharmaca Research Center, Bogor Agricultural University (IPB), Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Antimicrobial activity of Jatropha curcas Linn, seedcake from biofuel production has been studied. For safety evaluation, mutagenic and cytotoxic test were carried out. The seedcake was extracted by maceration method with methanol. The antimicrobial activity, cytotoxicity test, and mutagenic effect were determined by disc diffusion, Brine Shrimp Lethality Test (BSLT), and Ames test method, respectively. The methanolic extract of J. curcas seedcake and fractions extract showed potent antimicrobial activity against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and Candida albicans at minimum inhibitory concentration (MIC) of ≤ 1 mg/mL. The cytotoxicity value (LC 50) of methanolic extract of J. curcas seedcake was 22.12 μg/mL and had no mutagenicity effect against Salmonella typhimurium TA 1535. From this investigation it is evident that J. curcas seedacake from biofuel production might have promising biological activities including antimicrobial and cytotoxic properties. Therefore it could be a good source of natural medicine.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Antimicrobial,Cytotoxicity,Jatropha curcas seedcake,Mutagenic effect[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]