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Ameliorative Effect of Etlingera calophrys (K.Schum.) Rhizome Ethanolic Extract on High Fat Diet-Induced Obese Zebrafish Kesan Memperbaikkan Ekstrak Etanol Rizom Etlingera calophrys (K.Schum.) pada Diet Teraruh Tinggi Lemak Ikan Belang Obes
Idrus L.S.a, Fakri F.a, Hartati R.a, Saraswaty V.b, Ketut Adnyana I.a
a Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Institute of Technology Bandung, Bandung, Indonesia
b Research Unit for Clean Technology, Indonesian Institute of Sciences, Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2020 Penerbit Universiti Kebangsaan Malaysia. All rights reserved.Obesity is a major factor associated with inflammatory and various metabolic syndromes. Etlingera caloprhys, an Indonesia plant native from Southeast Sulawesi, is traditionally used years as daily food ingredient by local communities. The present paper presents an in vitro and in vivo study related to the anti-obesity effects of Etlingera caloprhys ethanol extract (ECEE). An experiment was conducted to evaluate in vitro pancreatic lipase enzyme (PLE) inhibition and in vivo anti-obesity activity in high fat diet (HFD) induced obese zebrafish fed with 10% w/w and 20% w/w ECEE-HFD were evaluated. To confirm anti-obesity activity, a set of obesity and biochemistry parameters i.e. body weight, body mass index (BMI), triglyceride and blood glucose levels, were monitored. Additionally, gene expression levels related to obesity i.e. adiponectin and PPARγ in visceral adipose tissue (VAT) were also evaluated. The results showed that ECEE significantly (p <0.05) inhibited PLE activity with an inhibition concentration (IC)50 of below 100 µg/mL. The HFD induced obese zebrafish fed with 10% w/w and 20% w/w ECEE-HFD showed decreasing body weight and BMI. The biochemistry parameters of the HFD-induced obese zebrafish fed with 10% w/w ECEE-HFD obviously displayed optimum reduction of triglycerides and blood glucose levels. More importantly, the gene expression confirmed that ECEE suppressed adipogenesis in VAT. Hence, ECEE is suggested as a potent alternative medicine for prevention of metabolic syndromes related to obesity.[/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Author keywords" size="size-sm" text_align="text-left"][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Indexed keywords" size="size-sm" text_align="text-left"][vc_column_text]Anti-obesity,Etlingera calophrys,Pancreatic lipase,Zebrafish[/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Funding details" size="size-sm" text_align="text-left"][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="DOI" size="size-sm" text_align="text-left"][vc_column_text]https://doi.org/10.17576/jsm-2020-4902-17[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]